We measured the zinc content of blood, the zinc concentration of the cerebrospinal fluid (CSF) and the motor and sensory conduction velocities of the median nerve. We studied zinc metabolism in patients with diabetes mellitus in an attempt to identify a connection between low zinc concentrations, impaired glucose metabolism and peripheral neuropathy. As zinc is essential for insulin metabolism, reduced dietary zinc intake in these patients may lead to neuropathy. Diabetes mellitus is the most common cause of peripheral neuropathy, which often goes undiagnosed or is inadequately treated. Zinc is an essential trace element involved in the metabolism of carbohydrates, lipids and proteins.
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